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Hepatic biotransformation of MLN8054 was researched in vitro employing human liver S9 fractions (Details on file, Millennium). Glucuronidation on the carboxylate moiety of MLN8054 to an acyl glucuronide was the predominant mechanism of biotransformation, Hydroxylation in the azepine moiety of MLN8054 was the foremost period 1 biotransformation path

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